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Tricyclic antidepressants / Apoptosis / Programmed cell death / Death / Glioma / Clomipramine / Antidepressant / Selective serotonin reuptake inhibitor / Biology / Cell biology / Brain tumor


Radiol Oncol 2006; 40(2): [removed]review The role of tricyclic drugs in selective triggering of mitochondrially-mediated apoptosis in neoplastic glia: a therapeutic option in malignant glioma?
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Document Date: 2009-10-02 02:48:34


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City

London / Haywards Heath / /

Company

Berthold Technologies / Cambrex Biosciences / Beckman Coulter / Pilkington / Samantha Dickson Research Trust / /

Country

United Kingdom / /

Currency

pence / /

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Facility

Institute of Biomedical / University of Portsmouth / Hurstwood Park Neurological Centre / King’s College Hospital / /

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IndustryTerm

Live cell imaging / cancer therapies / culture media / energy source / respiratory chain / metabolic product / software programme / chemical structure / /

MedicalCondition

glioma cell lines / anaplastic astrocytoma / human malignant glioma cells / glioma cultures / lymphoma / glioma cells / seizures / glial tumours / paediatric brain tumour / acid Many brain tumour / glioma / C6 rat glioma / tricyclic drug-mediated brain tumour / brain tumours / gliomas / glioblastoma primary cultures / human brain tumour / low grade pilocytic astrocytoma / hepatoma / solid cancers / human malignant glioma cell lines / high grade malignancy medulloblastoma / breast cancer / brain tumour / cancer / human neuroblastoma cells / glioblastoma multiforme / increased neuroblastoma cell necrosis / tumour / anaplastic astrocytoma line / brain neoplasms / malignant glioma / primary and secondary brain tumours / Epilepsy / human glioma cells / glioma patients taking clomipramine / leukaemia cells / thyroid cancer / human glioma / also mediate cancer / human glioma biopsies / tumours / /

MedicalTreatment

chemotherapy / radiotherapy / cancer therapies / drug therapy / /

OperatingSystem

Openlab / /

Organization

King’s College Hospital / Institute of Biomedical and Biomolecular Sciences / School of Pharmacy & Biomedical Sciences / Hurstwood Park Neurological Centre / Institute of Biomedical & Biomolecular Sciences / University of Portsmouth / School of Pharmacy and Biomedical Sciences / Portsmouth and 2Hurstwood Park Neurological Centre / /

Person

Heath West Sussex / G.J. Pilkington / /

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Position

Professor / /

Product

dexamethasone / Clomipramine / valproic acid / adenosine / /

Technology

antibodies / stem cells / apoptosis / gene expression / chemotherapy / by triggering mitochondrially-mediated apoptosis / /

URL

www.port.ac.uk/brainlab / www.sdrt.co.uk / /

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