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Blindness / Anatomy / Vascular endothelial growth factor / PEDF / Diabetic retinopathy / Ranibizumab / Hypoxia-inducible factors / Angiogenesis / Bevacizumab / Angiology / Medicine / Biology


PNAS PLUS Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy Savalan Babapoor-Farrokhrana,1, Kathleen Jeea,1, Brooks Puchnera, Syed Juna
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Document Date: 2015-05-22 15:03:31


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File Size: 1,25 MB

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City

MIO / Tarrytown / Baltimore / Chongqing / Santa Cruz / /

Company

IgG / Life Technologies / ABC / Marneros AG / EPO / Qiagen / Regeneron Pharmaceuticals Inc. / Charles River Laboratories / Pearson / Maldonado AE / Cayman Pharmaceuticals / BD Biosciences / Bio-Rad / Microsoft / /

Currency

pence / USD / /

/

Event

FDA Phase / /

Facility

University College London Institute of Ophthalmology / Wilmer Eye Institute / University of Maryland / Johns Hopkins University Pharmacy / The First Affiliated Hospital of Chongqing Medical University / /

IndustryTerm

reagents/analytic tools / serum starvation media / treatment of other diseases / conditioned media / treatment of ocular neovascular disease / therapy for diabetic eye disease / Diabetes Care / treatment of PDR and other ocular neovascular diseases / /

MedicalCondition

glaucoma / retinal neovascularization Babapoor-Farrokhran / macular edema / JE / proliferative diabetic retinopathy Savalan Babapoor-Farrokhrana / epidemic / D iabetic eye disease / sustained hyperglycemia / retinal detachment / dysfunction / macular degeneration / vitreous hemorrhage / retinopathy of prematurity / inflammatory mediators / inflammatory cytokines / Kaposi’s sarcoma / age-related macular degeneration / pivotal age-related macular degeneration / proliferative diabetic retinopathy / serum starvation / end-stage renal disease / MS / ocular neovascular diseases / blindness / China Diabetic eye disease / hypoxic breast cancer / diabetic retinopathy / Chronic inhibition / diabetic retinopathy severity / ocular neovascular disease / vision-threatening diseases / diabetic eye disease / diabetes / Prevent Blindness / experimental diabetic retinopathy / diabetes mellitus / diseases / retinal neovascularization / diabetic macular edema / retinal vein occlusion / early diabetes / less expensive blindness / ischemic retinal disease / corneal neovascularization / cataract / vascular metastasis / /

MedicalTreatment

surgery / /

Organization

Wilmer Eye Institute / Greenebaum Cancer Center / National Eye Institute / Institutional Review Board / the Johns Hopkins University / Association for Research / University of Maryland / Department of Pathology / Johns Hopkins University Animal Care and Use Committee / Chongqing Medical University / School of Dentistry / Johns Hopkins University / Ella Owens Medical Research Foundation / PDR (red) / University College London Institute of Ophthalmology / Medicare / Institute for Cell Engineering / and Departments of Pediatrics / NS NS / Johns Hopkins University School of Medicine / First Affiliated Hospital / Prevent Blindness Foundation / /

Person

Tao Mab / Sharon Solomona / Savalan Babapoor-Farrokhrana / Monika Deshpandea / Super Signal West Femto (Thermo) / Arch Klin / Akrit Sodhia / Brooks Puchnera / Astrid Limb / Silvia Montanerb / Ella Owens / Kathleen Jeea / George D. Yancopoulos / Syed Junaid Hassana / Gregg L. Semenzad / Adam Wenicka / Arch Ophthalmol / Gerard A. Luttya / /

/

Position

ischemia-driven mediator / multifunctional molecular player / mediator / Author / critical mediator / potent angiogenic mediator / Representative / angiogenic mediator / /

Product

Intravitreal injection / penicillin / triamcinolone / Intravitreous injections / digoxin / Tao / PDR / /

ProgrammingLanguage

EC / /

ProvinceOrState

Maryland / New York / /

Region

sub-Saharan Africa / /

Technology

Radiation / siRNA / antibodies / Cell Signaling / laser / gene expression / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1423765112 / www.pnas.org/lookup/suppl/doi / /

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